Oropharyngeal cancer: Optimal therapeutic approach not easily defined

  • No valid comparative studies
    • Surgery +/- postoperative (chemo)radiation
    • Primary chemoradiation
  • No single therapeutic regimen offers clear-cut, superior survival advantage
  • Optimal approach aims for
    • Single modality treatment for early tumours
    • Minimum treatment morbidity and mortality
    • Optimal functional outcome (swallowing, speech)
    • Cost-efficiency
  • Therapeutic choice therefore requires
    • Careful review of each case
      • Staging
      • General physical condition
      • Emotional reserves
      • Social and financial support
      • Likelihood of regular follow-up
    • Availability of supportive care (including nutrition), speech and swallowing rehabilitation and salvage treatment
    • Experience of treating team

Index: Clinical Practice Guidelines for Oropharyngeal Cancer

Resource Appropriate Oropharyngeal Cancer Guideline Scenarios